Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

More than 2 million people in the United States have myalgic encephalomyelitis/chronic
fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain …

Highlights•Trypanosoma cruzi parasites and Chagas disease show specific
tropism.•Metabolism is implicated in T. cruzi parasite tropism and Chagas disease …

Chagas disease (CD), caused by Trypanosoma cruzi (T. cruzi) protozoa, is a complicated
parasitic illness with inadequate medical measures for diagnosing infection and monitoring …

Chagas disease (CD) is a parasitic disease caused by Trypanosoma cruzi protozoa,
presenting with cardiomyopathy, megaesophagus, and/or megacolon. To determine the …

Acute kidney injury (AKI) is a systemic disease associated with widespread effects on distant
organs, including the heart. Normal cardiac function is dependent on constant ATP …

Obligate intracellular pathogens satisfy their nutrient requirements by coupling to host
metabolic processes, often modulating these pathways to facilitate access to key …

Untargeted metabolomic analysis is a powerful tool used for the discovery of novel
biomarkers. Chagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical …

Small molecules (less than 1,500 Da) include major biological signals that mediate host-
pathogen-microbiome communication. They also include key intermediates of metabolism …

Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is one of nineteen
neglected tropical diseases. CD is a vector-borne disease transmitted by triatomines, but CD …