The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

Role of neuroinflammation in amyotrophic lateral sclerosis: cellular mechanisms and therapeutic implications

J Liu, F Wang - Frontiers in immunology, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …

Mesenchymal stem cells in health and disease

A Uccelli, L Moretta, V Pistoia - Nature reviews immunology, 2008 - nature.com
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can
be isolated from many adult tissues. They can differentiate into cells of the mesodermal …

Stem cell paracrine actions and tissue regeneration

PR Baraniak, TC McDevitt - Regenerative medicine, 2010 - Taylor & Francis
Stem cells have emerged as a key element of regenerative medicine therapies due to their
inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous …

Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling

X Zhang, F Hu, G Li, G Li, X Yang, L Liu, R Zhang… - Cell death & …, 2018 - nature.com
Mesenchymal stem cells (MSCs) have been reported to localize in colorectal carcinomas,
and participate in the formation of the tumor microenvironment. They have recently been …

Immunomodulatory properties of mesenchymal stromal cells

AJ Nauta, WE Fibbe - Blood, The Journal of the American …, 2007 - ashpublications.org
Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitor cells
capable of differentiating into multiple lineages of the mesenchyme. MSCs have emerged as …

Double‐edged sword of mesenchymal stem cells: cancer‐promoting versus therapeutic potential

HY Lee, IS Hong - Cancer science, 2017 - Wiley Online Library
Mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, cord blood, and
other tissues, have recently attracted much attention as potential therapeutic agents in …

Mesenchymal stem cells and cancer: clinical challenges and opportunities

W Lin, L Huang, Y Li, B Fang, G Li… - BioMed research …, 2019 - Wiley Online Library
Stem cell‐based therapies exhibit profound therapeutic potential for treating various human
diseases, including cancer. Among the cell types that can be used for this purpose …

Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy

B Sohrabi, B Dayeri, E Zahedi, S Khoshbakht… - Cancer Gene …, 2022 - nature.com
Mesenchymal stem cells (MSCs) are known as promising sources for cancer therapy and
can be utilized as vehicles in cancer gene therapy. MSC-derived exosomes are central …