Pathophysiology and preclinical relevance of experimental graft-versus-host disease in humanized mice
Graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic
hematopoietic cell transplantations (allo-HCT) used for the treatment of hematological …
hematopoietic cell transplantations (allo-HCT) used for the treatment of hematological …
Tocilizumab increases regulatory T cells, reduces natural killer cells and delays graft‐versus‐host disease development in humanized mice treated with post …
C Sligar, P Cuthbertson, NA Miles… - … and Cell Biology, 2023 - Wiley Online Library
Graft‐versus‐host disease (GVHD) is a life‐threatening complication following donor
hematopoietic stem cell transplantation, where donor T cells damage host tissues. This …
hematopoietic stem cell transplantation, where donor T cells damage host tissues. This …
Insights into mechanisms of graft-versus-host disease through humanised mouse models
Graft-versus-host disease (GVHD) is a major complication that occurs following allogeneic
haematopoietic stem cell transplantation (HSCT) for the treatment of haematological cancers …
haematopoietic stem cell transplantation (HSCT) for the treatment of haematological cancers …
P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model
P Cuthbertson, NJ Geraghty, SR Adhikary… - Clinical …, 2021 - portlandpress.com
Graft-versus-host disease (GVHD) is a severe inflammatory response arising from
allogeneic haematopoietic stem cell transplantation. Previous studies revealed that …
allogeneic haematopoietic stem cell transplantation. Previous studies revealed that …
Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease
P Cuthbertson, SR Adhikary, NJ Geraghty… - Clinical …, 2020 - portlandpress.com
Background: Allogeneic haematopoietic stem cell transplantation (HSCT) is a curative
therapy for blood cancers; but results in the development of graft-versus-host disease …
therapy for blood cancers; but results in the development of graft-versus-host disease …
Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft‐versus‐host disease
NJ Geraghty, D Watson… - Immunology and Cell …, 2019 - Wiley Online Library
Allogeneic hematopoietic stem cell transplantation is a curative therapy for a number of
hematological malignancies, but is limited by the development of graft‐versus‐host disease …
hematological malignancies, but is limited by the development of graft‐versus‐host disease …
Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice
SR Adhikary, NJ Geraghty, P Cuthbertson, R Sluyter… - Purinergic …, 2019 - Springer
Graft-versus-host disease (GVHD) is a life-threatening consequence of allogeneic
haematopoietic stem cell transplantation, a curative therapy for haematological …
haematopoietic stem cell transplantation, a curative therapy for haematological …
Immunomodulation by juglone alleviates acute graft‐versus‐host disease without compromising the graft‐versus‐leukaemia activity in mice
D Gohil, KA Gandhi, SK Gupta, P Gera… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Acute graft‐versus‐host disease (GVHD) remains a major barrier
to successful transplantation outcomes. Recent studies have shown that pharmacotherapy …
to successful transplantation outcomes. Recent studies have shown that pharmacotherapy …
Graft‐versus‐leukaemia immunity is retained following treatment with post‐transplant cyclophosphamide alone or combined with tocilizumab in humanised mice
C Sligar, E Reilly, P Cuthbertson… - Clinical & …, 2024 - Wiley Online Library
Objectives Donor haematopoietic stem cell transplantation treats leukaemia by inducing
graft‐versus‐leukaemia (GVL) immunity. However, this benefit is often mitigated by graft …
graft‐versus‐leukaemia (GVL) immunity. However, this benefit is often mitigated by graft …
A single‐nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft‐versus‐host disease in a humanized mouse …
SR Adhikary, P Cuthbertson, RJ Turner… - … and Cell Biology, 2020 - Wiley Online Library
Regulatory T cells (Tregs) protect against graft‐versus‐host disease (GVHD), a life‐
threatening complication of allogeneic hematopoietic stem cell transplantation. The …
threatening complication of allogeneic hematopoietic stem cell transplantation. The …