The liver is the most important organ for biological transformation in the body and is crucial
for maintaining the body's vital activities. Liver injury is a serious pathological condition that …

Abstract Background The management of Graves' disease (GD) in the US is shifting towards
increased use of anti‐thyroid drugs (ATD). If patients fail to achieve remission after a …

Betaine is a derivative of the amino acid glycine widely investigated for its hepatoprotective
properties against alcoholism. The protective properties of betaine in different other …

Xenobiotic safety assessment is an area that impacts a multitude of different industry sectors
such as medicinal drugs, agrochemicals, industrial chemicals, cosmetics and environmental …

Objective Abnormal serum liver function tests are common in patients with untreated
thyrotoxicosis, even prior to the initiation of antithyroidal medications that may worsen the …

Drug‐induced liver injury (DILI) is a major concern in clinical studies as well as in
postmarketing surveillance. It is necessary to establish an animal model of DILI for thorough …

Methimazole is the most frequently prescribed antithyroid agent. On the other hand, several
cases of liver injury are attributed to this drug. The mechanism of methimazole-induced liver …

Background: The xenobiotics-induced liver injury is a clinical complication. Hence, finding
new hepatoprotective strategies has clinical value. Oxidative stress and its subsequent …

Liver injury is a deleterious adverse effect associated with methimazole administration, and
reactive intermediates are suspected to be involved in this complication. Glyoxal is an …

Background: Thiazolidinediones (TZDs) are widely used for treatment of type II diabetes
mellitus in humans. The first drug of this class, troglitazone, was withdrawn from the market …