Revealing protein–lncRNA interaction

F Ferre, A Colantoni… - Briefings in …, 2016 - academic.oup.com
Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of
which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs …

A commitment for life: Decades of unraveling the molecular mechanisms behind seed dormancy and germination

N Sajeev, M Koornneef, L Bentsink - The Plant Cell, 2024 - academic.oup.com
Seeds are unique time capsules that can switch between 2 complex and highly interlinked
stages: seed dormancy and germination. Dormancy contributes to the survival of plants …

RBPmap: a web server for mapping binding sites of RNA-binding proteins

I Paz, I Kosti, M Ares Jr, M Cline… - Nucleic acids …, 2014 - academic.oup.com
Regulation of gene expression is executed in many cases by RNA-binding proteins (RBPs)
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …

Prediction of RNA-protein sequence and structure binding preferences using deep convolutional and recurrent neural networks

X Pan, P Rijnbeek, J Yan, HB Shen - BMC genomics, 2018 - Springer
Background RNA regulation is significantly dependent on its binding protein partner, known
as the RNA-binding proteins (RBPs). Unfortunately, the binding preferences for most RBPs …

A deep learning framework for modeling structural features of RNA-binding protein targets

S Zhang, J Zhou, H Hu, H Gong, L Chen… - Nucleic acids …, 2016 - academic.oup.com
RNA-binding proteins (RBPs) play important roles in the post-transcriptional control of
RNAs. Identifying RBP binding sites and characterizing RBP binding preferences are key …

RNA structure drives interaction with proteins

N Sanchez de Groot, A Armaos… - Nature …, 2019 - nature.com
The combination of high-throughput sequencing and in vivo crosslinking approaches leads
to the progressive uncovering of the complex interdependence between cellular …

A 5′ UTR language model for decoding untranslated regions of mRNA and function predictions

Y Chu, D Yu, Y Li, K Huang, Y Shen, L Cong… - Nature Machine …, 2024 - nature.com
Abstract The 5′ untranslated region (UTR), a regulatory region at the beginning of a
messenger RNA (mRNA) molecule, plays a crucial role in regulating the translation process …

Destruction of DNA‐binding proteins by programmable oligonucleotide PROTAC (O'PROTAC): effective targeting of LEF1 and ERG

J Shao, Y Yan, D Ding, D Wang, Y He, Y Pan… - Advanced …, 2021 - Wiley Online Library
DNA‐binding proteins, including transcription factors (TFs), play essential roles in various
cellular processes and pathogenesis of diseases, deeming to be potential therapeutic …

Interpretation of deep learning in genomics and epigenomics

A Talukder, C Barham, X Li, H Hu - Briefings in Bioinformatics, 2021 - academic.oup.com
Abstract Machine learning methods have been widely applied to big data analysis in
genomics and epigenomics research. Although accuracy and efficiency are common goals …

RNA sequence context effects measured in vitro predict in vivo protein binding and regulation

JM Taliaferro, NJ Lambert, PH Sudmant, D Dominguez… - Molecular cell, 2016 - cell.com
Many RNA binding proteins (RBPs) bind specific RNA sequence motifs, but only a small
fraction (∼ 15%–40%) of RBP motif occurrences are occupied in vivo. To determine which …