Peptide-based liquid droplets as emerging delivery vehicles

J Liu, E Spruijt, A Miserez, R Langer - Nature Reviews Materials, 2023 - nature.com
Peptides are small yet versatile building blocks of biomaterials. This Comment highlights
recent progress in the design of liquid-like microdroplets, or coacervates, based on peptides …

How to drink like a liposome

J Liu, BZ Tang - Nature Reviews Chemistry, 2023 - nature.com
How to drink like a liposome | Nature Reviews Chemistry Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Multifaceted cargo recruitment and release from artificial membraneless organelles

J Liu, F Zhorabek, T Zhang, JWY Lam, BZ Tang… - Small, 2022 - Wiley Online Library
Liquid‐liquid phase separation (LLPS) drives membraneless organelles (MLOs) formation
for organizing biomolecules. Artificial MLOs (AMLOs) have been constructed mostly via the …

Molecular logic operations from complex coacervation with aggregation-induced emission characteristics

J Liu, T Zhang, X Liu, JWY Lam, BZ Tang, Y Chau - Materials Horizons, 2022 - pubs.rsc.org
Leveraging complex coacervation of a polycation and a bivalent anion with aggregation-
induced emission characteristics, we accomplish eight basic logic operations with …

Nucleic acids modulate liquidity and dynamics of artificial membraneless organelles

J Liu, F Zhorabek, Y Chau - ACS Macro Letters, 2022 - ACS Publications
Liquid–liquid phase separation (LLPS) emerges as a fundamental underlying mechanism
for the biological organization, especially the formation of membraneless organelles (MLOs) …

[HTML][HTML] Construction of multiphasic membraneless organelles towards spontaneous spatial segregation and directional flow of biochemical reactions

F Zhorabek, MS Abesekara, J Liu, X Dai, J Huang… - Chemical …, 2023 - pubs.rsc.org
Many intracellular membraneless organelles (MLOs) appear to adapt a hierarchical
multicompartment organization for efficient coordination of highly complex reaction …

Engineered Artificial Membraneless Organelles in Saccharomyces cerevisiae To Enhance Chemical Production

P Zhou, H Liu, X Meng, H Zuo, M Qi… - Angewandte Chemie …, 2023 - Wiley Online Library
Microbial cell factories provide a green and sustainable opportunity to produce value‐added
products from renewable feedstock. However, the leakage of toxic or volatile intermediates …

Engineering status of protein for improving microbial cell factories

P Zhou, C Gao, W Song, W Wei, J Wu, L Liu… - Biotechnology …, 2024 - Elsevier
With the development of metabolic engineering and synthetic biology, microbial cell
factories (MCFs) have provided an efficient and sustainable method to synthesize a series of …

[HTML][HTML] Biomaterial design inspired by membraneless organelles

J Liu, F Zhorabek, Y Chau - Matter, 2022 - cell.com
Membraneless organelles (MLOs) are phase-separated liquid compartments providing
spatiotemporal control of biomolecules and metabolism within cells. While MLOs exhibit …

Large-sized but ready to enter: Micron-sized liquid droplets for versatile intracellular delivery

J Liu, R Feng, Y Chau - Matter, 2022 - cell.com
Nanoparticles have been largely designed and exploited for intracellular delivery of
biomacromolecules, classically via endocytosis pathways. A recent work published by …