Necrotizing enterocolitis: new insights into pathogenesis and mechanisms

DF Niño, CP Sodhi, DJ Hackam - Nature reviews Gastroenterology & …, 2016 - nature.com
Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal
tract of preterm infants. At present, NEC is thought to develop in the premature host in the …

Contemporary outcomes for infants with necrotizing enterocolitis—a systematic review

IH Jones, NJ Hall - The Journal of pediatrics, 2020 - Elsevier
Objective To develop an accurate understanding of outcomes for necrotizing enterocolitis
(NEC) to inform parental counseling, clinical care, and research agendas. Study design A …

Necrotizing enterocolitis: It's not all in the gut

AL Meister, KK Doheny… - Experimental biology and …, 2020 - journals.sagepub.com
Necrotizing enterocolitis is the leading cause of death due to gastrointestinal disease in
preterm neonates, affecting 5–12% of neonates born at a very-low birth weight. Necrotizing …

Human milk oligosaccharides increase mucin expression in experimental necrotizing enterocolitis

RY Wu, B Li, Y Koike, P Määttänen… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope Necrotizing enterocolitis (NEC) is a leading cause of morbidity and death in preterm
infants, occurring more often in formula‐fed than breastfed infants. Studies in both rats and …

Para-probiotics for preterm neonates—The next frontier

G Deshpande, G Athalye-Jape, S Patole - Nutrients, 2018 - mdpi.com
Current evidence supports the use of probiotics in preterm neonates for prevention of
necrotizing enterocolitis, mortality and late onset sepsis. Despite the strong evidence, the …

Persistent pulmonary hypertension of the newborn in late preterm and term infants in California

MA Steurer, LL Jelliffe-Pawlowski, RJ Baer… - …, 2017 - publications.aap.org
METHODS: The California Office of Statewide Health Planning and Development maintains
a database linking maternal and infant hospital discharges, readmissions, and birth and …

[HTML][HTML] Current knowledge of necrotizing enterocolitis in preterm infants and the impact of different types of enteral nutrition products

J Shulhan, B Dicken, L Hartling, BMK Larsen - Advances in nutrition, 2017 - Elsevier
Preterm infants are extremely vulnerable to a range of morbidities and mortality.
Underdeveloped cardiac, respiratory, gastrointestinal, and immune systems in the preterm …

[HTML][HTML] A novel role for necroptosis in the pathogenesis of necrotizing enterocolitis

AD Werts, WB Fulton, MR Ladd, A Saad-Eldin… - Cellular and molecular …, 2020 - Elsevier
Background & Aims Necrotizing enterocolitis (NEC) is a devastating disease of premature
infants characterized by Toll-like receptor 4 (TLR4)-dependent intestinal inflammation and …

Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice

Y Liu, M Perego, Q Xiao, Y He, S Fu… - The Journal of …, 2019 - Am Soc Clin Investig
Inflammation plays a critical role in the development of severe neonatal morbidities. Myeloid-
derived suppressor cells (MDSCs) were recently implicated in the regulation of immune …

Neonatal intestinal dysbiosis in necrotizing enterocolitis

NL Denning, JM Prince - Molecular Medicine, 2018 - Springer
Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in
neonates, particularly among preterm infants in whom surgical NEC is the leading cause of …