Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

Oxidative stress is important in the pathophysiology of obesity, altering regulatory factors of
mitochondrial activity, modifying the concentration of inflammation mediators associated with …

Doxorubicin (DOX), a chemotherapeutic agent, induces a cardiotoxicity referred to as
doxorubicin-induced cardiomyopathy (DIC). This cardiotoxicity often limits chemotherapy for …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

Carotenoids are lipophilic isoprenoid compounds synthesized by all photosynthetic
organisms and some non-photosynthetic prokaryotes and fungi. With some notable …

As the most voluminous organ of the body that is exposed to the outer environment, the skin
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …

The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …