Placentation is a reproductive adaptation that permits fetal growth and development within
the protected confines of the female reproductive tract. Through this important role, the …

The mouse is often used as a model for understanding human placentation and offers
multiple advantages, including the ability to manipulate gene expression in specific …

Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …

The blastocyst (the early mammalian embryo) forms all embryonic and extra-embryonic
tissues, including the placenta. It consists of a spherical thin-walled layer, known as the …

INTRODUCTION Early mammalian development requires the formation of embryonic and
extraembryonic tissues and a highly coordinated partnership between them. This close …

Mammalian blastocysts comprise three distinct cell lineages essential for development
beyond implantation: the pluripotent epiblast, which generates the future embryo, and …

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and
the germline but are excluded from the extra-embryonic tissues that are derived from the …

The embryo instructs the allocation of cell states to spatially regulate functions. In the
blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and …

Generating cells with the molecular and functional properties of embryo cells and with full
developmental potential is an aim with fundamental biological significance. Here we report …

The difficulty of studying post-implantation development in mammals has sparked a flurry of
activity to develop in vitro models, termed embryoids, based on self-organizing pluripotent …