Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …

Adipose tissue is a major regulator of metabolism in health and disease. The prominent
roles of adipose tissue are to sequester fatty acids in times of energy excess and to release …

Queens and workers of eusocial Hymenoptera are considered homologous to the
reproductive and brood care phases of an ancestral subsocial life cycle. However, the …

The aim of this study was to carry out a systematic review and meta-analysis of the effects of
caffeine supplementation on physiological responses to submaximal exercise. A total of 26 …

Adenosine is an endogenous nucleoside that regulates many physiological and
pathological processes. It is derived from either the intracellular or extracellular …

Extracellular adenosine is a ubiquitous signaling molecule that modulates a wide array of
biological processes. Recently, significant advances have been made in our understanding …

Aim: Although obesity is becoming epidemic all around the world, the effort to reduce its
prevalence has not been effective. Thus, there is a need to find further paths to prevent …

Hyperlipidemia is associated with endothelial dysfunction and inflammatory disorders.
Adenosine and adenosine deaminase (ADA) modulate immune responses and lipid …

Platelets are small anucleated cells present only in mammals. Platelets mediate
intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in …

G protein-coupled receptors (GPCRs) are cell surface receptors that mediate the function of
extracellular ligands. Understanding how GPCRs work at the molecular level has important …