Advances in TRP channel drug discovery: from target validation to clinical studies
AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
B Nilius, A Szallasi - Pharmacological reviews, 2014 - ASPET
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer
JL Saloman, KM Albers, D Li… - Proceedings of the …, 2016 - National Acad Sciences
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an exuberant inflammatory
desmoplastic response. The PDAC microenvironment is complex, containing both pro-and …
desmoplastic response. The PDAC microenvironment is complex, containing both pro-and …
Mechanisms of cancer dissemination along nerves
The local extension of cancer cells along nerves is a frequent clinical finding for various
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …
Role of the nervous system in cancers: a review
H Wang, Q Zheng, Z Lu, L Wang, L Ding, L Xia… - Cell death …, 2021 - nature.com
Nerves are important pathological elements of the microenvironment of tumors, including
those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent …
those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent …
TRP channels as potential drug targets
MM Moran - Annual review of pharmacology and toxicology, 2018 - annualreviews.org
The transient receptor potential (TRP) superfamily of channels comprises a diverse group of
cation channels. Four TRP channel subunits coassemble to form functional homo-or …
cation channels. Four TRP channel subunits coassemble to form functional homo-or …
Chalcone derivatives: anti-inflammatory potential and molecular targets perspectives
Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold has gained considerable scientific
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …
The role of transient receptor potential vanilloid 1 in common diseases of the digestive tract and the cardiovascular and respiratory system
Q Du, Q Liao, C Chen, X Yang, R Xie, J Xu - Frontiers in Physiology, 2019 - frontiersin.org
Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …
New insights into the pathogenesis of pancreatitis
Recent advances challenge the long-believed trypsin-centered understanding of
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …