Botulinum neurotoxins: biology, pharmacology, and toxicology

M Pirazzini, O Rossetto, R Eleopra, C Montecucco… - Pharmacological …, 2017 - Elsevier
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …

Botulinum neurotoxins: genetic, structural and mechanistic insights

O Rossetto, M Pirazzini, C Montecucco - Nature Reviews Microbiology, 2014 - nature.com
Botulinum neurotoxins (BoNTs) are produced by anaerobic bacteria of the genus
Clostridium and cause a persistent paralysis of peripheral nerve terminals, which is known …

Identification and characterization of a novel botulinum neurotoxin

S Zhang, G Masuyer, J Zhang, Y Shen, D Lundin… - Nature …, 2017 - nature.com
Botulinum neurotoxins are known to have seven serotypes (BoNT/A–G). Here we report a
new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with …

Botulinum and tetanus neurotoxins

M Dong, G Masuyer, P Stenmark - Annual review of …, 2019 - annualreviews.org
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins
known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as …

The microbiome of New World vultures

M Roggenbuck, I Bærholm Schnell, N Blom… - Nature …, 2014 - nature.com
Vultures are scavengers that fill a key ecosystem niche, in which they have evolved a
remarkable tolerance to bacterial toxins in decaying meat. Here we report the first deep …

Pathogenicity and virulence of Clostridium botulinum

AM Rawson, AW Dempster, CM Humphreys… - Virulence, 2023 - Taylor & Francis
Clostridium botulinum, a polyphyletic Gram-positive taxon of bacteria, is classified purely by
their ability to produce botulinum neurotoxin (BoNT). BoNT is the primary virulence factor …

[HTML][HTML] Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium

S Zhang, F Lebreton, MJ Mansfield, SI Miyashita… - Cell host & …, 2018 - cell.com
Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of
potent bacterial toxins and potential bioterrorism agents. Here we report that an …

Immunogenicity of botulinum toxin formulations: potential therapeutic implications

WW Carr, N Jain, JW Sublett - Advances in therapy, 2021 - Springer
Botulinum neurotoxins (BoNTs) are proteins produced by bacteria of the Clostridium family.
Upon oral ingestion, BoNT causes the neuroparalytic syndrome botulism. There are seven …

Pharmaceutical, biological, and clinical properties of botulinum neurotoxin type A products

J Frevert - Drugs in R&D, 2015 - Springer
Botulinum neurotoxin injections are a valuable treatment modality for many therapeutic
indications and have revolutionized the field of aesthetic medicine so that they are the …

Immunogenicity of botulinum toxins

M Naumann, LM Boo, AH Ackerman… - Journal of neural …, 2013 - Springer
Botulinum neurotoxins are formulated biologic pharmaceuticals used therapeutically to treat
a wide variety of chronic conditions, with varying governmental approvals by country. Some …