BACKGROUND Myelin, produced by oligodendrocytes, supports the rapid and
synchronized transfer of information across the central nervous system (CNS). Earlier views …

Structural plasticity in the myelinated infrastructure of the nervous system has come to light.
Although an innate program of myelin development proceeds independent of nervous …

Studies of activity-driven nervous system plasticity have primarily focused on the gray matter.
However, MRI-based imaging studies have shown that white matter, primarily composed of …

Activity of the nervous system has long been recognized as a critical modulator of brain
structure and function. Influences of experience on the cytoarchitecture and functional …

Myelinating oligodendrocytes enable fast propagation of action potentials along the
ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including …

Within the past decade, multiple lines of evidence have converged to identify a critical role
for activity-regulated myelination in tuning the function of neural networks. In this Review, we …

Axons are ultrathin membrane cables that are specialized for the conduction of action
potentials. Although their diameter is variable along their length, how their morphology is …

The study of structural and functional plasticity in the central nervous system (CNS) to date
has focused primarily on that of neurons and synapses. However, more recent studies …

Plasticity of myelination represents a mechanism to tune the flow of information by balancing
functional requirements with metabolic and spatial constraints. The auditory system is …

Myelin allows for the rapid and precise timing of action potential propagation along neuronal
circuits and is essential for healthy auditory system function. In this article, we discuss what …