We analyze the fundamental functions of Prune_1 in brain pathophysiology. We discuss the
importance and maintenance of the function of Prune_1 and how its perturbation influences …

Prune exopolyphosphatase 1 (PRUNE1) is a short-chain phosphatase that is part of the
aspartic acid-histidine-histidine (DHH) family of proteins. PRUNE1 is highly expressed in the …

Hereditary spinocerebellar degenerations (SCDs) is an umbrella term that covers a group of
monogenic conditions that share common pathogenic mechanisms and include hereditary …

Consanguineous marriage is prevalent in certain world regions due to cultural, economic,
and social reasons. However, it can lead to negative consequences including an increased …

Hereditary spinocerebellar degenerative disorders (SCDs) is an umbrella term that covers a
group of monogenic conditions that share common pathogenic mechanisms and include …

Epilepsy represents a wide spectrum of phenotypes with various etiologies and
comorbidities. Genetic predisposition to epilepsy is conferred by rare variants and common …