Intracellular mRNA transport and localized translation
Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …
precise temporal and spatial control of gene expression. High-resolution imaging …
RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis
S Zhu, JZ Wang, D Chen, YT He, N Meng… - Nature …, 2020 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic RNAs.
The biological importance of m6A relies on m6A readers, which control mRNA fate and …
The biological importance of m6A relies on m6A readers, which control mRNA fate and …
[HTML][HTML] The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer
D Ramesh-Kumar, S Guil - Seminars in Cancer Biology, 2022 - Elsevier
RNA binding proteins that act at the post-transcriptional level display a richness of
mechanisms to modulate the transcriptional output and respond to changing cellular …
mechanisms to modulate the transcriptional output and respond to changing cellular …
IGF2BP3 promotes mRNA degradation through internal m7G modification
Recent studies have suggested that mRNA internal m7G and its writer protein METTL1 are
closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP …
closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP …
First small-molecule inhibitors targeting the RNA-binding protein IGF2BP2/IMP2 for cancer therapy
C Dahlem, A Abuhaliema, SM Kessler… - ACS chemical …, 2022 - ACS Publications
The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is overexpressed in several tumor
entities, promotes tumorigenesis and tumor progression, and has been suggested to worsen …
entities, promotes tumorigenesis and tumor progression, and has been suggested to worsen …
Circular RNA circ‐TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA
X Pan, B Huang, Q Ma, J Ren, Y Liu… - Clinical and …, 2022 - Wiley Online Library
Background Clear cell renal cell carcinoma (ccRCC) is a common malignant tumour of the
urinary tract. The major causes of poor prognosis are the lack of early diagnosis and …
urinary tract. The major causes of poor prognosis are the lack of early diagnosis and …
The diverse functions of IMP2/IGF2BP2 in metabolism
N Dai - Trends in Endocrinology & Metabolism, 2020 - cell.com
The human insulin-like growth factor 2 (IGF2) mRNA binding protein family (IMPs/IGF2BPs)
is involved in a spectrum of biological processes, including development, tumorigenesis …
is involved in a spectrum of biological processes, including development, tumorigenesis …
SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice
T Yoshizawa, Y Sato, SU Sobuz, T Mizumoto… - Nature …, 2022 - nature.com
Brown adipose tissue plays a central role in the regulation of the energy balance by
expending energy to produce heat. NAD+-dependent deacylase sirtuins have widely been …
expending energy to produce heat. NAD+-dependent deacylase sirtuins have widely been …
CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502–5p/KRAS and IGF2BP2/Myc axes
J Li, X Gao, Z Zhang, Y Lai, X Lin, B Lin, M Ma, X Liang… - Molecular cancer, 2021 - Springer
Background Emerging studies have revealed the potent functions of circRNAs in breast
cancer tumorigenesis. However, the biogenesis, biofunction and mechanism of circRNAs in …
cancer tumorigenesis. However, the biogenesis, biofunction and mechanism of circRNAs in …