Light levels, refractive development, and myopia–a speculative review

TT Norton, JT Siegwart Jr - Experimental eye research, 2013 - Elsevier
Recent epidemiological evidence in children indicates that time spent outdoors is protective
against myopia. Studies in animal models (chick, macaque, tree shrew) have found that light …

Optical mechanisms regulating emmetropisation and refractive errors: evidence from animal models

R Chakraborty, LA Ostrin… - Clinical and …, 2020 - Taylor & Francis
Our current understanding of emmetropisation and myopia development has evolved from
decades of work in various animal models, including chicks, non‐human primates, tree …

[HTML][HTML] Form-deprivation myopia in the guinea pig (Cavia porcellus)

MHC Howlett, SA McFadden - Vision research, 2006 - Elsevier
Form deprivation (FD) was induced in 61 guinea pigs with a diffuser worn on one eye. The
form-deprived eye elongated and developed myopia within 6 days in animals raised under a …

[HTML][HTML] Long-wavelength (red) light produces hyperopia in juvenile and adolescent tree shrews

TJ Gawne, AH Ward, TT Norton - Vision Research, 2017 - Elsevier
In infant tree shrews, exposure to narrow-band long-wavelength (red) light, that stimulates
long-wavelength sensitive cones almost exclusively, slows axial elongation and produces …

[HTML][HTML] Regulation of the mechanical properties of tree shrew sclera by the visual environment

JT Siegwart Jr, TT Norton - Vision research, 1999 - Elsevier
Experiments in several species have shown that the axial elongation rate of the developing
eye can be increased or decreased by manipulating the visual environment, indicating that a …

[HTML][HTML] Induced myopia associated with increased scleral creep in chick and tree shrew eyes

JR Phillips, M Khalaj… - … ophthalmology & visual …, 2000 - jov.arvojournals.org
purpose. To investigate the role of scleral creep in the axial elongation of chick and tree
shrew eyes with induced myopia. methods. Form-deprivation myopia was induced with a …

Animal models of myopia: learning how vision controls the size of the eye

TT Norton - ILAR journal, 1999 - academic.oup.com
As they grow up, approximately 25% of children in the United States become myopic
(nearsighted)(Sperduto and others 1983). A much smaller percentage become significantly …

The wavelength composition and temporal modulation of ambient lighting strongly affect refractive development in young tree shrews

TJ Gawne, JT Siegwart Jr, AH Ward… - Experimental eye research, 2017 - Elsevier
Shortly after birth, the eyes of most animals (including humans) are hyperopic because the
short axial length places the retina in front of the focal plane. During postnatal development …

[HTML][HTML] The susceptible period for deprivation-induced myopia in tree shrew

JT Siegwart Jr, TT Norton - Vision Research, 1998 - Elsevier
To examine the susceptible period for deprivation-induced myopia, six groups of tree shrew
pups (Tupaia glis belangeri) were monocularly deprived for 12 days with an opaque …

[HTML][HTML] The time course of changes in mRNA levels in tree shrew sclera during induced myopia and recovery

JT Siegwart, TT Norton - Investigative ophthalmology & visual …, 2002 - arvojournals.org
purpose. In tree shrews, visual form deprivation produces increased axial elongation of the
deprived eye and a myopic shift in refractive state. A change in scleral extensibility (creep …