Antioxidant and oxidative stress: a mutual interplay in age-related diseases

BL Tan, ME Norhaizan, WPP Liew… - Frontiers in …, 2018 - frontiersin.org
Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

Pharmacological potential of tocotrienols: a review

H Ahsan, A Ahad, J Iqbal, WA Siddiqui - Nutrition & metabolism, 2014 - Springer
Tocotrienols, members of the vitamin E family, are natural compounds found in a number of
vegetable oils, wheat germ, barley, and certain types of nuts and grains. Like tocopherols …

Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases

BB Aggarwal, C Sundaram, S Prasad… - Biochemical …, 2010 - Elsevier
Initially discovered in 1938 as a “fertility factor,” vitamin E now refers to eight different
isoforms that belong to two categories, four saturated analogues (α, β, γ, and δ) called …

Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Z Zainal, H Khaza'ai, AK Radhakrishnan… - Food Research …, 2022 - Elsevier
Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …

Vitamin E decreases bone mass by stimulating osteoclast fusion

K Fujita, M Iwasaki, H Ochi, T Fukuda, C Ma… - Nature medicine, 2012 - nature.com
Bone homeostasis is maintained by the balance between osteoblastic bone formation and
osteoclastic bone resorption,,. Osteoclasts are multinucleated cells that are formed by …

Potential role of tocotrienols on non-communicable diseases: a review of current evidence

SK Wong, Y Kamisah, N Mohamed, N Muhammad… - Nutrients, 2020 - mdpi.com
Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties.
This review aimed to summarize the health benefits of T3, particularly in prevention or …

The molecular mechanism of vitamin E as a bone-protecting agent: a review on current evidence

SK Wong, NV Mohamad, NI Ibrahim, KY Chin… - International journal of …, 2019 - mdpi.com
Bone remodelling is a tightly-coordinated and lifelong process of replacing old damaged
bone with newly-synthesized healthy bone. In the bone remodelling cycle, bone resorption …

[HTML][HTML] Therapeutic potential of annatto tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss

NV Mohamad, S Ima-Nirwana, KY Chin - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Tocotrienol has been shown to prevent bone loss in animal models of postmenopausal
osteoporosis, but the low oral bioavailability might limit its use. A self-emulsifying drug …

Nutritional studies of rice bran oil

OM Lai, JJ Jacoby, WF Leong, WT Lai - Rice bran and rice bran oil, 2019 - Elsevier
Rice bran oil (RBO) is not a popular oil worldwide, but its demand is increasing due to its
popularity as a “healthy oil” in Asian countries, particularly in Japan, Korea, India, China …

The biological effects of tocotrienol on bone: A review on evidence from rodent models

KY Chin, S Ima-Nirwana - Drug design, development and therapy, 2015 - Taylor & Francis
Osteoporosis causes significant health care and economic burden to society, leading to a
relentless search for effective preventive agents. Tocotrienol, a member of the vitamin E …