Highlights•Synthetic biology approaches enable microbial systems engineering.•Versatile
tools rapidly expand regulatory engineering capabilities.•Modular components and …

In multicellular organisms, gene regulatory circuits generate thousands of molecularly
distinct, mitotically heritable states through the property of multistability. Designing synthetic …

Synthetic biology enables the design of gene networks to confer specific biological
functions, yet it remains a challenge to rationally engineer a biological trait as complex as …

Chromatin instability and mitochondrial decline are conserved processes that contribute to
cellular aging. Although both processes have been explored individually in the context of …

Cells in diverse organisms can store the information of previous environmental conditions
for long periods of time. This form of cellular memory adjusts the cell's responses to future …

The epithelial–mesenchymal transition (EMT) is a basic developmental process that
converts epithelial cells to mesenchymal cells. Although EMT might promote cancer …

Tumor heterogeneity is a primary cause of treatment failure and acquired resistance in
cancer patients. Even in cancers driven by a single mutated oncogene, variability in …

Growth-mediated feedback between synthetic gene circuits and host organisms leads to
diverse emerged behaviors, including growth bistability and enhanced ultrasensitivity …

Failure of modularity remains a significant challenge for assembling synthetic gene circuits
with tested modules as they often do not function as expected. Competition over shared …

Dimension reduction is a challenging problem in complex dynamical systems. Here, a
dimension reduction approach of landscape (DRL) for complex dynamical systems is …