Hepatic ischemia-reperfusion injury (HIRI) is the major complication of liver surgery and liver
transplantation, that may increase the postoperative morbidity, mortality, tumor progression …

Chronic liver injury results in cirrhosis and end-stage liver disease (ESLD) which represents
a leading cause of death worldwide, affecting people in their most productive years of life …

Background Body mass index (BMI) and lipid parameters are the most commonly used
anthropometric parameters and biomarkers for assessing nonalcoholic fatty liver disease …

Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic
Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated …

Drug-induced organ toxicity/injury, especially in the liver, kidney, and gastrointestinal tract, is
a systematic disorder that causes oxidative stress formation and inflammation resulting in …

Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the
key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a …

Brucine (BRU) and brucine N-oxide (BNO) are prominent, bioactive, and toxic alkaloids in
crude and processed Semen Strychni. Studies have demonstrated that BRU and BNO …

Abstract Microcystin-LR (MC-LR) is a potent hepatotoxin produced by harmful
cyanobacterial blooms (CyanoHABs). MC-LR targets highly differentiated hepatocytes …

Background DNA methylation, a biochemical modification of cytosine, has an important role
in lipid metabolism. Fatty liver hemorrhagic syndrome (FLHS) is a serious disease and is …

Hepatocellular carcinoma (HCC), one of the most common tumours worldwide, is one of the
main causes of mortality in cancer patients. There are still numerous problems hindering its …