Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Abstract Imidazo [1, 2-b] pyridazine scaffold represents an important class of heterocyclic
nucleus which provides various bioactives molecules. Among them, the successful kinase …

Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyrazine series
led to the identification of highly potent compounds against the blood life-cycle stage of the …

Plasmodium falciparum phosphatidylinositol 4-kinase (Pf PI4K) has emerged as a promising
new drug target for novel antimalarial therapeutics. In the absence of a reliable high …

A single copper (II)-catalyzed three-component cascade aminomethylation/
cycloisomerization of propiolates to form imidazo [1, 2-a] pyridines was explored. A …

Therapies addressing multiple stages of Plasmodium falciparum life cycle are highly
desirable for implementing malaria elimination strategies. MMV019918 (1, 1-[5-(4-bromo-2 …

DFT‐calculations allow prediction of the reactivity of uncommon N‐heterocyclic scaffolds of
pyrazolo [1, 5‐a] pyrimidines and imidazo [1, 2‐b] pyridazines and considerably facilitate …

Conspectus New, safe and effective drugs are urgently needed to treat and control malaria
and tuberculosis, which affect millions of people annually. However, financial return on …

Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) is one of the eukaryotic
protein kinases that were identified as essential for the parasite causing malaria tropica …

Heterocycles, heteroaromatics and spirocyclic entities are ubiquitous components of a wide
plethora of synthetic drugs, biologically active natural products, marketed pharmaceuticals …