The mitophagy pathway and its implications in human diseases

S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - Signal transduction and …, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

The role of mitochondrial fission in cardiovascular health and disease

JM Quiles, ÅB Gustafsson - Nature Reviews Cardiology, 2022 - nature.com
Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics

JC Campos, LH Marchesi Bozi… - Proceedings of the …, 2023 - National Acad Sciences
Exercise is a nonpharmacological intervention that improves health during aging and a
valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently …

[HTML][HTML] Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

YJ Liu, RL McIntyre, GE Janssens… - Mechanisms of ageing …, 2020 - Elsevier
The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass

V Romanello, M Sandri - Cellular and Molecular Life Sciences, 2021 - Springer
The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

The protective role of exercise against age-related neurodegeneration

A Sujkowski, L Hong, RJ Wessells, SV Todi - Ageing Research Reviews, 2022 - Elsevier
Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

OPA1 regulation of mitochondrial dynamics in skeletal and cardiac muscle

J Noone, DJ O'Gorman, HC Kenny - Trends in Endocrinology & Metabolism, 2022 - cell.com
The mitochondria are double-membrane organelles integral for energy metabolism.
Mitochondrial dynamics is regulated by inner and outer mitochondrial membrane (IMM and …

Dysregulated mitochondrial dynamics and metabolism in obesity, diabetes, and cancer

W Dai, L Jiang - Frontiers in endocrinology, 2019 - frontiersin.org
Metabolism describes the life-sustaining chemical reactions in organisms that provide both
energy and building blocks for cellular survival and proliferation. Dysregulated metabolism …

Interactions between insulin and exercise

EA Richter, L Sylow, M Hargreaves - Biochemical journal, 2021 - portlandpress.com
The interaction between insulin and exercise is an example of balancing and modifying the
effects of two opposing metabolic regulatory forces under varying conditions. While insulin is …

Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies

GB Kubat, E Bouhamida, O Ulger, I Turkel, G Pedriali… - Mitochondrion, 2023 - Elsevier
Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …