In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Metastatic progression is the main cause of death in cancer patients, whereas the
underlying genomic mechanisms driving metastasis remain largely unknown. Here, we …

A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …

Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-
associated inflammatory microenvironment aids tumor cells in metastatic colonization in …

Respiratory viral infections reprogram pulmonary macrophages with altered anti-infectious
functions. However, the potential function of virus-trained macrophages in antitumor …

Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …

Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …

Brain metastasis is a major cause of cancer mortality, but its molecular mechanisms are
severely understudied. In addition, little is known regarding the role of m 6 A reader YTHDF3 …