[HTML][HTML] Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: Metastasis, therapy response, and revisiting molecular pathways

E Sabouni, MM Nejad, S Mojtabavi… - Biomedicine & …, 2023 - Elsevier
Colorectal cancer (CRC) is a dangerous form of cancer that affects the gastrointestinal tract.
It is a major global health concern, and the aggressive behavior of tumor cells makes it …

Multifaceted roles of CCL20 (CC motif chemokine ligand 20): mechanisms and communication networks in breast cancer progression

LB Kwantwi, S Wang, Y Sheng, Q Wu - Bioengineered, 2021 - Taylor & Francis
Emerging studies have demonstrated notable roles of CCL20 in breast cancer progression.
Based on these findings, CCL20 has become a potential therapeutic target for cancer …

Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

SJ Hachey, CJ Hatch, D Gaebler, A Mocherla… - Breast Cancer …, 2024 - Springer
Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments.
Stromal cells in the tumor microenvironment (TME) are crucial in TNBC progression; …

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

N Li, Q Zhu, Y Tian, KJ Ahn, X Wang, Z Cramer… - Nature …, 2023 - nature.com
The initiation and progression of cancer are intricately linked to the tumor microenvironment
(TME). Understanding the function of specific cancer-TME interactions poses a major …

Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4

C Sun, C Shi, X Duan, Y Zhang, B Wang - Bioengineered, 2022 - Taylor & Francis
Hepatic fibrosis (HF) is a pathological phenomenon that occurs during the process of long-
term damage and repair in the liver. This condition will lead to the development of cirrhosis …

Proteome and metabolomic profile of Mongolian horse follicular fluid during follicle development

X Li, M Du, Y Liu, M Wang, Y Shen, J Xing, L Zhang… - Scientific Reports, 2024 - nature.com
During follicular development, changes in the composition of the follicular fluid are
synchronized with the development of oocytes. Our aim was to screen the key factors …

[HTML][HTML] Gene expression study of breast cancer using Welch Satterthwaite t-test, Kaplan-Meier estimator plot and Huber loss robust regression model

S Karim, MS Iqbal, N Ahmad, MS Ansari, Z Mirza… - Journal of King Saud …, 2023 - Elsevier
Abstract Objective Breast Cancer (BC) is one of the deadliest diseases in women, causing
thousands of deaths annually despite the advent of high-throughput genomic platforms in …

Establishment and characterization of cytochrome P450 1A1 CRISPR/Cas9 knockout bovine foetal hepatocyte cell line (BFH12)

S Iori, C D'Onofrio, N Laham-Karam… - Cell Biology and …, 2024 - Springer
Abstract The cytochrome P450 1A (CYP1A) subfamily of xenobiotic metabolizing enzymes
(XMEs) consists of two different isoforms, namely CYP1A1 and CYP1A2, which are highly …

INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation

H Zhang, Y Huang, Q Wen, Y Li, L Guo… - Journal of Orthopaedic …, 2023 - Springer
Background Osteosarcoma (OS) is a refractory malignancy. This study aimed to explore the
roles and mechanisms of Inhibin subunit beta A (INHBA) in OS. Methods INHBA expression …

Subpopulations of fibroblasts derived from human iPS cells

T Kobayashi, A Yamashita, N Tsumaki… - Communications …, 2024 - nature.com
Organ fibrosis causes collagen fiber overgrowth and impairs organ function. Cardiac fibrosis
after myocardial infarction impairs cardiac function significantly, pulmonary fibrosis reduces …