Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …

Multiple mechanisms mediate thrombin generation and consequently the thrombin
concentration present during fibrin formation. First, the levels of pro-and anticoagulants …

Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma
at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 …

Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …

Thrombosis can affect any venous circulation. Venous thromboembolism (VTE) includes
deep-vein thrombosis of the leg or pelvis, and its complication, pulmonary embolism. VTE is …

Venous thromboembolism (VTE), the third leading cause of cardiovascular mortality, is a
complex thrombotic disorder with environmental and genetic determinants. Although several …

Hereditary fibrinogen abnormalities comprise two classes of plasma fibrinogen defects: Type
I, afibrinogenemia or hypofibrinogenemia, which has absent or low plasma fibrinogen …

Fluid resuscitation after massive hemorrhage in major surgery and trauma may result in
extensive hemodilution and coagulopathy, which is of a multifactorial nature. Although …

Venous thrombosis (deep vein thrombosis, pulmonary embolism) is a common and serious
disorder, with genetic and acquired risk factors. The genetic risk factors can be subdivided in …

Fibrinogen is an extraordinary molecule by any estimation. It is large, structurally intricate,
and circulates at high concentrations. Its biological end product, insoluble fibrin (ogen) or …