Background Language impairment in Alzheimer's disease occurs early, and language
function deteriorates with progression of the illness to cause significant disability. This …

Research on apolipoprotein E (APOE) has consistently revealed a relationship between the
gene′ s ε4 allele and risk for development of Alzheimer′ s disease (AD). However …

Alzheimer's disease (AD) manifests with memory loss and spatial disorientation. AD
pathology starts in the entorhinal cortex, making it likely that local neural correlates of spatial …

Introduction The long preclinical phase of Alzheimer's disease provides opportunities for
potential disease-modifying interventions in prodromal stages such as mild cognitive …

We investigated the impact of APOE genotype on cerebral blood flow (CBF) in older and
younger adults. Forty cognitively normal older adults (16 ε4 carriers, 24 non-ε4 carriers) and …

Background Language deficits frequently occur during the prodromal stages of Alzheimer's
disease (AD). However, the characteristics of linguistic impairment and its underlying …

Background: There is a need to specify the profile of subjective cognitive decline in
preclinical Alzheimer's disease (preAD). Objectives: To explore specific items of the …

The apolipoprotein (APOE) ε4 allele has been proposed as an example of an antagonistic
pleiotropy gene, conferring a beneficial effect on cognition in early life and a detrimental …

The rising prevalence of type 2 diabetes (T2DM) and hypertension in older adults, and the
deleterious effect of these conditions on cerebrovascular and brain health, is creating a …

The apolipoprotein E (APOE) gene is associated with structural and functional brain
changes. We have used multiscale entropy (MSE) analysis to detect changes in the …