Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Ionized calcium (Ca2+) is the most versatile cellular messenger. All cells use Ca2+ signals
to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …

Store-operated calcium entry is a central mechanism in cellular calcium signalling and in
maintaining cellular calcium balance. This review traces the history of research on store …

Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …

Cell proliferation is orchestrated through diverse proteins related to calcium (Ca 2+)
signaling inside the cell. Cellular Ca 2+ influx that occurs first by various mechanisms at the …

Endothelial dysfunction is a major player in the development and progression of vascular
pathology in pulmonary arterial hypertension (PAH), a disease associated with small vessel …