Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

Background Dupilumab, a fully human monoclonal antibody that binds IL‐4Rα and inhibits
signaling of both IL‐4 and IL‐13, has shown efficacy across multiple diseases with …

Animal models remain invaluable for study of respiratory diseases, however, translation of
data generated in genetically homogeneous animals housed in a clean and well-controlled …

Clinical studies in asthma are not able to clear up all aspects of disease pathophysiology.
Animal models have been developed to better understand these mechanisms and to …

IL-33, a member of the IL-1-related cytokines, is considered to be a proallergic cytokine that
is especially involved in Th2-type immune responses. Moreover, like IL-1α, IL-33 has been …

House dust mite-derived proteases contribute to allergic disorders in part by disrupting
epithelial barrier function. Interleukin-33 (IL-33), produced by lung cells after exposure to …

Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also
contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and …

Asthma is a very complex and heterogeneous disease that is characterized by airway
inflammation and airway hyper-reactivity (AHR). The pathogenesis of asthma is associated …

Background Asthma in a mouse model spontaneously resolves after cessation of allergen
exposure. We developed a mouse model in which asthma features persisted for 6 months …