Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …

Cutaneous melanoma is the most common skin cancer with an incidence that has been
rapidly increasing in the past decades. Melanomas are among the most immunogenic …

Melanoma cells can switch between a melanocytic and a mesenchymal-like state. Scattered
evidence indicates that additional intermediate state (s) may exist. Here, to search for such …

Simple Summary Melanoma is a major public health issue that claims the lives of thousands
of people every year. Furthermore, the outlook for the coming years is not encouraging with …

Epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial transition (MET) plays
critical roles in cancer metastasis. Recent studies, especially those based on single‐cell …

Schwann cell precursors (SCPs) are nerve‐associated progenitors that can generate
myelinating and non‐myelinating Schwann cells but also are multipotent like the neural …

Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Melanoma is a highly aggressive tumour that can metastasize very early in disease
progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We …

Cancer is a large group of diseases and the second leading cause of death worldwide.
Lung, prostate, colorectal, stomach, and liver cancers are the most common types of cancer …

Background PD-1-based immune checkpoint inhibition (ICI) is the major backbone of current
melanoma therapy. Tumor PD-L1 expression represents one of few biomarkers predicting …