The ultimate origin of Lewy body disorders, including Parkinson's disease (PD) and
Dementia with Lewy bodies (DLB), is still incompletely understood. Although a large number …

The heterogeneity of Parkinson's disease (PD), ie the various clinical phenotypes,
pathological findings, genetic predispositions and probably also the various implicated …

The brain-and body-first models of Lewy body disorders predict that aggregated alpha-
synuclein pathology usually begins in either the olfactory system or the enteric nervous …

Background: The α-syn Origin site and Connectome model (SOC) proposes that α-
synucleinopathies can be divided into two categories: the asymmetrical brain-first, and more …

Parkinson's disease (PD) unfolds with pathological processes and neurodegeneration well
before the emergence of noticeable motor symptoms, providing a window for early …

The question whether Parkinson's disease dementia (PDD) and dementia with Lewy bodies
(DLB) are expressions of the same underlying disease has been vigorously debated for …

Parkinson's disease (PD) involves both the central nervous system (CNS) and enteric
nervous system (ENS), and their interaction is important for understanding both the clinical …

Background Isolated rapid eye movement sleep behavior disorder (iRBD) is a clinically
important parasomnia syndrome preceding α-synucleinopathies, thereby prompting us to …

Abstract Parkinson's disease (PD), the second most prevalent neurodegenerative disorder,
was classically attributed to alpha-synuclein aggregation and consequent loss of …

Cardiac 123I-MIBG scintigraphy is used to assess the function of postganglionic presynaptic
cardiac sympathetic nerve endings. 123I-MIBG cardiac uptake is markedly reduced in …