The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and
regulating vascular integrity. In patients with chronic kidney disease, protective endothelial …

Drugs acting by inhibition of the angiogenic action of VEGF (vascular endothelial growth
factor) have become major instruments in the treatment of cancer. The downside of their …

Axl is a tyrosine kinase receptor, a negative regulator for innate immune responses and
inflammatory bowel disease (IBD). The gut microbiota regulates intestinal immune …

To assess the contribution of individual TGF-β isoforms to aortopathy in Marfan syndrome
(MFS), we quantified the survival and phenotypes of mice with a combined fibrillin1 (the …

Background: Few studies have investigated the hemodynamic mechanism whereby primary
aldosteronism causes hypertension. The traditional view holds that hyperaldosteronism …

Aortic dissection is a devastating cardiovascular disease with a high lethality. Histone
variants maintain the genomic integrity and play important roles in development and …

It is now apparent that immune mediators including complement, cytokines, and cells of the
innate and adaptive immune system contribute not only to blood pressure elevation but also …

The healthy adult aorta exhibits a remarkable homeostatic ability to respond to sustained
changes in hemodynamic loads under many circumstances, but this mechanical …

The immune system is an emerging regulator of hemostasis and thrombosis. The concept of
immunothrombosis redefines the relationship between coagulation and immunomodulation …

Abstract Fifty years ago, Dr. John Laragh brought forward the “vasoconstriction-volume
hypothesis” of hypertension. This is Ohm's Law in blood pressure regulation, explicating …