Guanosine is a purine nucleoside with important functions in cell metabolism and a
protective role in response to degenerative diseases or injury. The past decade has seen …

Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released
in the brain under physiological conditions and even more during pathological events …

Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually
worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in …

Atherosclerosis is an inflammatory disease due to a diet high in saturated fat,
hypercholesterolemia, obesity, hypoglycemia, etc. mainly mediated by the infiltration of …

The function of guanine-based purines (GBPs) is mostly attributed to the intracellular
modulation of heteromeric and monomeric G proteins. However, extracellular effects of …

Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …

In the present review, we stress the importance of the purine nucleosides, adenosine and
guanosine, in protecting the nervous system, both centrally and peripherally, via activation of …

Neuronal and synaptic loss are the best pathological correlates for memory decline in
Alzheimer's disease (AD). Soluble beta-amyloid oligomers (AβO) are considered to …

Guanosine is a guanine-based purine that modulates glutamate uptake and exerts
neurotrophic and neuroprotective effects. In a previous study, our group demonstrated that …

Stroke is the major cause of death and the most frequent cause of disability in the adult
population worldwide. Guanosine plays an important neuroprotective role in several …