Melatonin is a natural occurring compound with well‐known antioxidant properties.
Melatonin is ubiquitously distributed and because of its small size and amphiphilic nature, it …

Melatonin is a ubiquitous natural neurotransmitter-like compound produced primarily by the
pineal gland. This agent is involved in numerous aspects of the biological and physiologic …

Premature ovarian failure (POF) is a major side effect of chemotherapy in young cancer
patients. To develop pharmaceutical agents for preserving fertility, it is necessary to …

Cisplatin (CDDP) is one of the most active cytotoxic agents in the treatment of cancer and
has adverse side effects such as nephrotoxicity and hepatotoxicity. The present study was …

This study evaluated the receptor-and/or antioxidant stress-mediated mechanisms by which
melatonin prevents the ovarian toxicity of cisplatin treatment. The expression of the MT1 …

Despite its broad applications, cisplatin affords considerable nephro-and hepatotoxicity
through triggering inflammatory and oxidative stress cascades. The aim of the current …

Oxidative stress is considered to be the main cause of diabetic complications. As the role of
antioxidants in diabetes therapy is still underestimated, the aim of the present investigation …

In this study, we investigated the effect of melatonin on cisplatin‐induced spermiotoxicity
using quantitative, biochemical and histopathological approaches. Cisplatin (CP, 7 mg/kg) …

OBJECTIVE: To evaluate the effect of melatonin on cyclophosphamide (CP)-and cisplatin-
induced testicular toxicity with use of sperm parameters and biochemical and …

The toxicity of aminoglycosides including gentamicin (GEN), the most widely used drug in
this category, is believed to be related to the generation of reactive oxygen species (ROS) in …