The prefrontal cortex, pathological anxiety, and anxiety disorders

MM Kenwood, NH Kalin, H Barbas - Neuropsychopharmacology, 2022 - nature.com
Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

Z Yan, B Rein - Molecular psychiatry, 2022 - nature.com
The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

Neural mechanisms of aggression across species

JE Lischinsky, D Lin - Nature neuroscience, 2020 - nature.com
Aggression is a social behavior essential for securing resources and defending oneself and
family. Thanks to its indispensable function in competition and thus survival, aggression …

A synaptic threshold mechanism for computing escape decisions

DA Evans, AV Stempel, R Vale, S Ruehle, Y Lefler… - Nature, 2018 - nature.com
Escaping from imminent danger is an instinctive behaviour that is fundamental for survival,
and requires the classification of sensory stimuli as harmless or threatening. The absence of …

A neuronal circuit for activating descending modulation of neuropathic pain

J Huang, VM Gadotti, L Chen, IA Souza, S Huang… - Nature …, 2019 - nature.com
Neuropathic pain can be a debilitating condition with both sensory and affective
components, the underlying brain circuitry of which remains poorly understood. In the …

[HTML][HTML] Correlated neural activity and encoding of behavior across brains of socially interacting animals

L Kingsbury, S Huang, J Wang, K Gu, P Golshani… - Cell, 2019 - cell.com
Social interactions involve complex decision-making tasks that are shaped by dynamic,
mutual feedback between participants. An open question is whether and how emergent …

Silencing neurons: tools, applications, and experimental constraints

JS Wiegert, M Mahn, M Prigge, Y Printz, O Yizhar - Neuron, 2017 - cell.com
Reversible silencing of neuronal activity is a powerful approach for isolating the roles of
specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal …

History of winning remodels thalamo-PFC circuit to reinforce social dominance

T Zhou, H Zhu, Z Fan, F Wang, Y Chen, H Liang… - Science, 2017 - science.org
Mental strength and history of winning play an important role in the determination of social
dominance. However, the neural circuits mediating these intrinsic and extrinsic factors have …

Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli

CM Vander Weele, CA Siciliano, GA Matthews… - Nature, 2018 - nature.com
Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse
behavioural functions,; however, the precise circuit computations remain unknown. One …

Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus

K Tossell, X Yu, P Giannos, B Anuncibay Soto… - Nature …, 2023 - nature.com
The prefrontal cortex (PFC) enables mammals to respond to situations, including internal
states, with appropriate actions. One such internal state could be 'tiredness'. Here, using …