Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound

S Schoen Jr, MS Kilinc, H Lee, Y Guo… - Advanced drug delivery …, 2022 - Elsevier
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …

Therapeutic oxygen delivery by perfluorocarbon-based colloids

MP Krafft, JG Riess - Advances in colloid and interface science, 2021 - Elsevier
After the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/
phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed …

Ultrasound-responsive droplets for therapy: A review

H Lea-Banks, MA O'reilly, K Hynynen - Journal of Controlled Release, 2019 - Elsevier
The last two decades have seen the development of acoustically activated droplets, also
known as phase-change emulsions, from a diagnostic tool to a therapeutic agent. Through …

Phase-shift nanodroplets as an emerging sonoresponsive nanomaterial for imaging and drug delivery applications

W Zhang, Y Shi, S Abd Shukor, A Vijayakumaran… - Nanoscale, 2022 - pubs.rsc.org
Nanodroplets–emerging phase-changing sonoresponsive materials–have attracted
substantial attention in biomedical applications for both tumour imaging and therapeutic …

Nanobubbles: a promising efficient tool for therapeutic delivery

R Cavalli, M Soster, M Argenziano - Therapeutic delivery, 2016 - Taylor & Francis
In recent decades ultrasound-guided delivery of drugs loaded on nanocarriers has been the
focus of increasing attention to improve therapeutic treatments. Ultrasound has often been …

Blinking acoustic nanodroplets enable fast super-resolution ultrasound imaging

F Dong, J An, J Zhang, J Yin, W Guo, D Wang, F Feng… - Acs Nano, 2021 - ACS Publications
The advent of localization-based super-resolution ultrasound (SRUS) imaging creates a
vista for precision vasculature and hemodynamic measurements in brain science …

Methods of generating submicrometer phase-shift perfluorocarbon droplets for applications in medical ultrasonography

PS Sheeran, N Matsuura, MA Borden… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
Continued advances in the field of ultrasound and ultrasound contrast agents have created
new approaches to imaging and medical intervention. Phase-shift perfluorocarbon droplets …

Applications of sub-micron low-boiling point phase change contrast agents for ultrasound imaging and therapy

PG Durham, PA Dayton - Current Opinion in Colloid & Interface Science, 2021 - Elsevier
Phase change contrast agents (PCCAs) have been studied in the medical ultrasound field
for nearly three decades. Their ability to convert from a liquid core droplet to an acoustically …

Factors influencing the repeated transient optical droplet vaporization threshold and lifetimes of phase change, perfluorocarbon nanodroplets

AX Zhao, YI Zhu, E Chung, J Lee, S Morais, H Yoon… - Nanomaterials, 2023 - mdpi.com
Perfluorocarbon nanodroplets (PFCnDs) are sub-micrometer emulsions composed of a
surfactant-encased perfluorocarbon (PFC) liquid and can be formulated to transiently …

Intracellular delivery and ultrasonic activation of folate receptor-targeted phase-change contrast agents in breast cancer cells in vitro

JP Marshalek, PS Sheeran, P Ingram… - Journal of Controlled …, 2016 - Elsevier
Breast cancer is a diverse and complex disease that remains one of the leading causes of
death among women. Novel, outside-of-the-box imaging and treatment methods are needed …