The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …

All multicellular organisms rely on differential gene transcription regulated by genomic
enhancers, which function through cofactors that are recruited by transcription factors …

The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

The positive transcription elongation factor b (P-TEFb) is composed of cyclins T1 or T2 and
cyclin-dependent kinase 9 that regulate the elongation phase of transcription by RNA …

RNA molecules undergo a vast array of chemical post-transcriptional modifications (PTMs)
that can affect their structure and interaction properties. In recent years, a growing number of …

Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …

DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis
and to initiate repair signalling, but the mechanism to stall elongating RNA polymerase II …

Summary 7SK is a conserved noncoding RNA that regulates transcription by sequestering
the transcription factor P-TEFb. 7SK function entails complex changes in RNA structure, but …

The precise regulation of RNA Polymerase II (Pol II) transcription after genotoxic stress is
crucial for proper execution of the DNA damage-induced stress response. While stalling of …