Osteoporosis is a systemic skeletal disease caused by an imbalance between bone
resorption and formation. Current treatments primarily involve systemic medication and …

In recent years, researchers have become focused on the relationship between lipids and
bone metabolism balance. Moreover, many diseases related to lipid metabolism disorders …

Brain vascular calcification is a prevalent age-related condition often accompanying
neurodegenerative and neuroinflammatory diseases. The pathogenesis of large-vessel …

The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA)
remain unknown. No pharmacological intervention can currently prevent the progression of …

Background Osteoporosis and atherosclerosis are common in the elderly population,
conferring a heavy worldwide burden. Evidence links osteoporosis and atherosclerosis but …

Evidence suggests a unique association between bone aging and neurodegenerative/
cerebrovascular disorders. However, the mechanisms underlying bone‐brain interplay …

Type H vessels are specialized blood vessels found in the bone marrow that are closely
associated with osteogenic activity. They are characterized by high expression of …

In addition to reducing fracture risk, zoledronic acid has been found in some studies to
decrease mortality in humans and extend lifespan and healthspan in animals. Because …

Senescence is a complex cell state characterized by stable cell cycle arrest and a unique
secretory pattern known as the senescence-associated secretory phenotype (SASP). The …

Cardiovascular disease (CVD) and osteoporosis often occur together, suggesting an
association between CVD and bone loss. Similarly, the correlation of bone loss …