The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms

R Alaggio, C Amador, I Anagnostopoulos, AD Attygalle… - Leukemia, 2022 - nature.com
We herein present an overview of the upcoming 5th edition of the World Health Organization
Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid …

Genomic profiling for clinical decision making in lymphoid neoplasms

L De Leval, AA Alizadeh, PL Bergsagel… - Blood, The Journal …, 2022 - ashpublications.org
With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

Integrated molecular and immunological features of human T-lymphotropic virus type 1 infection and disease progression to adult T-cell leukaemia or lymphoma

JS O'Donnell, SK Hunt, KJ Chappell - The Lancet Haematology, 2023 - thelancet.com
The human T-lymphotropic virus type 1 (HTLV-1) retrovirus infects 10–20 million people
globally, with endemic regions in southwestern Japan, the Caribbean basin, Africa, and …

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma

K Izutsu, S Makita, K Nosaka, M Yoshimitsu… - Blood, 2023 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is an aggressive non-Hodgkin lymphoma with poor
prognosis and few treatment options for patients with relapsed, recurrent, or refractory …

GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms

X Geng, C Wang, X Gao, P Chowdhury, J Weiss… - Blood cancer …, 2022 - nature.com
Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets
account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms …

Linker histone variant H1. 2 is a brake on white adipose tissue browning

Y Yuan, Y Fan, Y Zhou, R Qiu, W Kang, Y Liu… - Nature …, 2023 - nature.com
Adipose-tissue is a central metabolic organ for whole-body energy homeostasis. Here, we
find that highly expressed H1. 2, a linker histone variant, senses thermogenic stimuli in …

CD30 expression and its functions during the disease progression of adult T-cell leukemia/lymphoma

M Nakashima, K Uchimaru - International Journal of Molecular Sciences, 2023 - mdpi.com
CD30, a member of the tumor necrosis factor receptor superfamily, plays roles in pro-
survival signal induction and cell proliferation in peripheral T-cell lymphoma (PTCL) and …

HTLV-1 persistence and the oncogenesis of adult T-cell leukemia/lymphoma

CRM Bangham - Blood, The Journal of the American Society of …, 2023 - ashpublications.org
Human T-cell leukemia virus type I (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL)
in 5% of infected people with a decades-long latency. Charles RM Bangham reviews the …

Feasibility and clinical utility of comprehensive genomic profiling of hematological malignancies

S Fukuhara, Y Oshikawa‐Kumade, Y Kogure… - Cancer …, 2022 - Wiley Online Library
Identification of genetic alterations through next‐generation sequencing (NGS) can guide
treatment decision‐making by providing information on diagnosis, therapy selection, and …

T-cell prolymphocytic leukemia: diagnosis, pathogenesis, and treatment

M Gutierrez, P Bladek, B Goksu… - International Journal of …, 2023 - mdpi.com
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells.
Most patients with T-PLL present with lymphocytosis, anemia, thrombocytopenia, and …