Viral reservoirs in elite controllers of HIV-1 infection: Implications for HIV cure strategies

BA Woldemeskel, AK Kwaa, JN Blankson - EBioMedicine, 2020 - thelancet.com
Elite controllers are HIV-1 positive subjects who control viral replication without antiretroviral
therapy. Many of these subjects have replication-competent virus and thus represent a …

HIV control: Is getting there the same as staying there?

P Goulder, SG Deeks - PLoS pathogens, 2018 - journals.plos.org
In this brief review and perspective, we address the question of whether the immune
responses that bring about immune control of acute HIV infection are the same as, or distinct …

CD8+ T-cell responses in HIV controllers: potential implications for novel HIV remission strategies

RL Rutishauser, L Trautmann - Current Opinion in HIV and AIDS, 2022 - journals.lww.com
We propose implications as to how this knowledge from natural infection can be applied in
the design and evaluation of CD8+ T-cell-based remission strategies and offer questions to …

Comparison of the Biological Basis for Non-HIV Transmission to HIV-Exposed Seronegative Individuals, Disease Non-Progression in HIV Long-Term Non …

J Hokello, P Tyagi, S Dimri, AL Sharma, M Tyagi - Viruses, 2023 - mdpi.com
HIV-exposed seronegative individuals (HESIs) are a small fraction of persons who are
multiply exposed to human immunodeficiency virus (HIV), but do not exhibit serological or …

A high prevalence of potential HIV elite controllers identified over 30 years in Democratic Republic of Congo

MG Berg, A Olivo, BJ Harris, MA Rodgers, L James… - …, 2021 - thelancet.com
Background In-depth analysis of the HIV pandemic at its epicenter in the Congo basin has
been hampered by 40 years of political unrest and lack of functional public health …

Transient plasma viral rebound after SARS-CoV-2 vaccination in an exceptional HIV-1 elite controller woman

L Di Girolamo, M Ferrara, G Trevisan, BM Longo… - Virology Journal, 2023 - Springer
Background Elite controllers are able to control viral replication without antiretroviral therapy.
Exceptional elite controllers do not show disease progression for more than 25 years …

HIV proviral burden, genetic diversity, and dynamics in viremic controllers who subsequently initiated suppressive antiretroviral therapy

FH Omondi, H Sudderuddin, A Shahid, NN Kinloch… - MBio, 2021 - Am Soc Microbiol
Curing HIV will require eliminating the reservoir of integrated, replication-competent
proviruses that persist despite antiretroviral therapy (ART). Understanding the burden …

The influence of HLA/HIV genetics on the occurrence of elite controllers and a need for therapeutics geotargeting view

LW Lunardi, MAS Bragatte, GF Vieira - Brazilian Journal of Infectious …, 2021 - SciELO Brasil
The interaction of HIV-1, human leukocyte antigen (HLA), and elite controllers (EC) compose
a still intricate triad. Elite controllers maintain a very low viral load and a normal CD4 count …

Additive quantile mixed effects modelling with application to longitudinal CD4 count data

AA Yirga, SF Melesse, HG Mwambi, DG Ayele - Scientific reports, 2021 - nature.com
Quantile regression offers an invaluable tool to discern effects that would be missed by other
conventional regression models, which are solely based on modeling conditional mean …

[HTML][HTML] Understanding the CD8 T-cell response in natural HIV control

S Boppana, P Goepfert - F1000Research, 2018 - ncbi.nlm.nih.gov
HIV-infected individuals who maintain control of virus without antiretroviral therapy (ART) are
called HIV controllers. The immune responses of these individuals suppress HIV viral …