In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked
during bone growth and regeneration in bone modeling and during bone homeostasis in …

Blood vessels and nerve fibers are distributed throughout the entirety of skeletal tissue, and
play important roles during bone development and fracture healing by supplying oxygen …

Objectives Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases
that frequently co-exist, along with overweight/obesity. While the mechanical impact of …

Osteonecrosis, also known as avascular necrosis or AVN, is characterized by a stereotypical
pattern of cell death and a complex repair process of bone resorption and formation. It is not …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

Bone is a highly vascularized tissue, although this aspect of bone is often overlooked. In this
article, the importance of blood flow in bone repair and regeneration will be reviewed. First …

Apoptotic death of osteocytes was recognized over 15years ago, but its significance for bone
homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte …

There is mounting evidence that vascular pathology plays a role in the initiation and/or
progression of the major disease of joints: osteoarthritis (OA). Potential mechanisms are …

Angiogenesis and osteogenesis are coupled. However, the cellular and molecular
regulation of these processes remains to be further investigated. Both tissues have recently …

Osteonecrosis of the femoral head (ONFH), a progressive pathological process of femoral
head ischemia and osteocyte necrosis, is a refractory orthopedic disease caused by multiple …