Hypothalamic syndrome (HS) is a rare disorder caused by disease-related and/or treatment-
related injury to the hypothalamus, most commonly associated with rare, non-cancerous …

A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

Sox2+ adult mouse pituitary cells can self-renew and terminally differentiate in vitro, but their
physiological role in vivo and possible contribution to oncogenesis remain largely unknown …

The genetic basis for combined pituitary hormone deficiency (CPHD) is complex, involving
30 genes in a variety of syndromic and nonsyndromic presentations. Molecular diagnosis of …

Pituitary hormone deficiencies, with Growth Hormone deficiency being most frequent (1 in
3,500-10,000 births), cause significant morbidity. Regeneration of missing endocrine cells …

Significant progress has been made recently in unravelling the embryonic events leading to
pituitary morphogenesis, both in vivo and in vitro. This includes dissection of the molecular …

The diagnosis of GH deficiency (GHD) in childhood is a multistep process involving clinical
history, examination with detailed auxology, biochemical testing, and pituitary imaging, with …

Owing to its complex structure and highly diverse cell populations, the study of hypothalamic
development has historically lagged behind that of other brain regions. However, in recent …

Many aspects of pituitary development have become better understood in the past two
decades. The signaling pathways regulating pituitary growth and shape have emerged, and …

It is unclear how loss-of-function germline mutations in the widely-expressed co-chaperone
AIP, result in young-onset growth hormone secreting pituitary tumours. The RET receptor …