Playing with the molecules of life

DD Young, PG Schultz - ACS chemical biology, 2018 - ACS Publications
Our understanding of the complex molecular processes of living organisms at the molecular
level is growing exponentially. This knowledge, together with a powerful arsenal of tools for …

Engineering enzymes for noncanonical amino acid synthesis

PJ Almhjell, CE Boville, FH Arnold - Chemical Society Reviews, 2018 - pubs.rsc.org
The standard proteinogenic amino acids grant access to a myriad of chemistries that
harmonize to create life. Outside of these twenty canonical protein building blocks are …

Novel artificial metalloenzymes by in vivo incorporation of metal-binding unnatural amino acids

I Drienovská, A Rioz-Martínez, A Draksharapu… - Chemical …, 2015 - pubs.rsc.org
Artificial metalloenzymes have emerged as an attractive new approach to enantioselective
catalysis. Herein, we introduce a novel strategy for preparation of artificial metalloenzymes …

Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis

B Brouwer, F Della-Felice, JH Illies… - Chemical …, 2024 - ACS Publications
Biocatalysis has become an important component of modern organic chemistry, presenting
an efficient and environmentally friendly approach to synthetic transformations. Advances in …

Taking orders from light: progress in photochromic bio-materials

J Zhang, J Wang, H Tian - Materials Horizons, 2014 - pubs.rsc.org
Photochromic materials are a family of compounds which undergo photo-reversible
transformations between two different isomers with distinct physical and chemical properties …

Remote B-ring oxidation of sclareol with an engineered P450 facilitates divergent access to complex terpenoids

F Li, H Deng, H Renata - Journal of the American Chemical …, 2022 - ACS Publications
Though chiral pool synthesis is widely accepted as a powerful strategy in complex molecule
synthesis, the effectiveness of the approach is intimately linked to the range of available …

Expanding the Genetic Code of Bioelectrocatalysis and Biomaterials

Y Chemla, F Kaufman, M Amiram, L Alfonta - Chemical Reviews, 2024 - ACS Publications
Genetic code expansion is a promising genetic engineering technology that incorporates
noncanonical amino acids into proteins alongside the natural set of 20 amino acids. This …

Recent progress in design of protein-based fluorescent biosensors and their cellular applications

T Tamura, I Hamachi - ACS chemical biology, 2014 - ACS Publications
Protein-based fluorescent biosensors have emerged as key bioanalytical tools to visualize
and quantify a wide range of biological substances and events in vitro, in cells, and even in …

Resurfaced fluorescent protein as a sensing platform for label-free detection of copper (II) ion and acetylcholinesterase activity

C Lei, Z Wang, Z Nie, H Deng, H Hu, Y Huang… - Analytical …, 2015 - ACS Publications
Protein engineering by resurfacing is an efficient approach to provide new molecular toolkits
for biotechnology and bioanalytical chemistry. H39GFP is a new variant of green fluorescent …

Biocatalytic Friedel‐Crafts Reactions

RB Leveson‐Gower, G Roelfes - ChemCatChem, 2022 - Wiley Online Library
Friedel‐Crafts alkylation and acylation reactions are important methodologies in synthetic
and industrial chemistry for the construction of aryl‐alkyl and aryl‐acyl linkages that are …