The integrins are a family of α, β heterodimeric receptors that mediate dynamic linkages
between extracellular adhesion molecules and the intracellular actin cytoskeleton. Integrins …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

Integrins are important adhesion receptors in all Metazoa that transmit conformational
change bidirectionally across the membrane. Integrin α and β subunits form a head and two …

The major platelet integrin, αIIbβ3, is required for platelet interactions with proteins in plasma
and the extracellular matrices (ECMs) that are essential for platelet adhesion and …

Integrins are transmembrane receptors that are central to the biology of many human
pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with …

▪ Abstract Integrins are a structurally elaborate family of heterodimers that mediate divalent
cation-dependent cell adhesion in a wide range of biological contexts. The inserted (I) …

Integrins are a structurally elaborate family of adhesion molecules that transmit signals bi-
directionally across the plasma membrane by undergoing large-scale structural …

Among adhesion receptor families, integrins are particularly important in biological
processes that require rapid modulation of adhesion and de‐adhesion. Activation on a …

Integrins are adhesion molecules that convey signals both to and from the cytoplasm across
the plasma membrane. In resting cells, integrins in a low affinity state can be activated …

Binding of fibrinogen to GPIIb‐IIIa on agonist‐stimulated platelets results in platelet
aggregation, presumably by crosslinking adjacent activated platelets. Although unactivated …