Abstract Purpose of Review To review the role of the immune cells and their interaction with
cells found in gingiva, periodontal ligament, and bone that leads to net bone loss in …

Orthodontic tooth movement (OTM) is generated by a mechanical force that induces an
aseptic inflammatory response in the periodontal tissues and a subsequent coordinated …

γδ T cells are nonclassical T lymphocytes representing the major T-cell population at
epithelial barriers. In the gingiva, γδ T cells are enriched in epithelial regions adjacent to the …

In recent years, cell therapy has come to play an important therapeutic role in oral diseases.
This paper reviews the active role of mesenchymal stem cells, immune cell sources, and …

Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and
destructive inflammation. The host's innate and adaptive immune responses produce pro …

Tooth movement is a complex process involving the vascularization of the tissues,
remodeling of the bone cells, and periodontal ligament fibroblasts under the hormonal and …

Pyroptosis, an inflammatory caspase-dependent programmed cell death, plays a vital role in
maintaining tissue homeostasis and activating inflammatory responses. Orthodontic tooth …

Periodontitis is one of the most common infectious diseases in humans. It is characterized by
a chronic inflammation of the tooth-supporting tissue that results in bone loss. However, the …

Objective This study investigated the effect of local semaphorin 3A (Sema3A) administration
on alveolar bone loss during OTM in a mouse model of periodontitis. Background …

Orthodontic tooth movement (OTM) is accomplished by controlling the mechanical loading
onto the bone around the roots of target teeth. The precise orthodontic force induces …