Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

The BCl-2 family has long been identified for its role in apoptosis. Following the initial
discovery of BCL-2 in the context of B-cell lymphoma in the 1980s, a number of homologous …

Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

It is now well established that tumours undergo changes in cellular metabolism 1. As this
can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose …

Cancer along with cardiovascular disease are the main causes of death in the industrialised
countries around the World. Conventional cancer treatments are losing their therapeutic …

Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …

Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Allosteric regulation of protein function is widespread in biology, but is challenging for de
novo protein design as it requires the explicit design of multiple states with comparable free …

Apoptosis is a critically important biological process that plays an essential role in cell fate
and homeostasis. An important component of the apoptotic pathway is the family of proteins …