Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and
ototoxic side-effects remain major clinical limitations. Recent studies have improved our …

Permanent hearing loss affects more than 5% of the world's population, yet there are no
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …

Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-
threatening bacterial infections, including tuberculosis, sepsis, respiratory infections in cystic …

Each year over half a million people experience permanent hearing loss caused by
treatment with therapeutic drugs with ototoxic side effects. There is a major unmet clinical …

Ototoxicity refers to damage of inner ear structures (ie, the cochlea and vestibule) and their
function (hearing and balance) following exposure to specific in-hospital medications (ie …

Aminoglycosides are widely used antibiotics with notable side effects, such as
nephrotoxicity, vestibulotoxicity, and sensorineural hearing loss (cochleotoxicity). MT‐RNR1 …

Purpose This review article summarizes our current understanding of the mechanisms
underlying acquired hearing loss from hospital-prescribed medications that affects as many …

Oxidative stress has been established as the key mechanism of the cochlear damage
underlying noise-induced hearing loss, however, emerging evidence suggests that cochlear …

A significant number of studies support the idea that inflammatory responses are intimately
associated with drug-, noise-and age-related hearing loss (DRHL, NRHL and ARHL) …

The Ototoxicity Working Group of Pharmaceutical Interventions for Hearing Loss defined
ototoxicity as damage to the inner ear, targeting cochlear and vestibular structures as well as …