Centromeres are the eukaryotic chromosomal sites at which the kinetochore forms and
attaches to spindle microtubules to orchestrate chromosomal segregation in mitosis and …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

In most plants, centromeric DNA contains highly repetitive sequences, including tandem
repeats and retrotransposons; however, the roles of these sequences in the structure and …

Pioneering advances in genome engineering, and specifically in genome writing, have
revolutionized the field of synthetic biology, propelling us toward the creation of synthetic …

Centromeres are the genomic regions that organize and regulate chromosome behaviours
during cell cycle, and their variations are associated with genome instability, karyotype …

Kinetochore assembly on centromeres is central for chromosome segregation, and defects
in this process cause mitotic errors and aneuploidy. Besides the well-established protein …

The centromere is essential for ensuring high-fidelity transmission of chromosomes. CENP-
A, the centromeric histone H3 variant, is thought to be the epigenetic mark of centromere …

Centromeric chromatin plays a crucial role in kinetochore assembly and chromosome
segregation. Centromeres are specified through the loading of the histone H3 variant CENP …

Forcing budding yeast to chromatinize their DNA with human histones manifests an abrupt
fitness cost. We previously proposed chromosomal aneuploidy and missense mutations as …