Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

As principais alterações fisiopatológicas das doenças falciformes são revistas, levando em
conta três níveis: a) moléculas e células, b) tecidos, c) organismo completo. Dedica-se …

The chronic inflammatory state in sickle cell anemia (SCA) is associated with several factors
such as the following: endothelial damage; increased production of reactive oxygen species; …

As hemoglobinas variantes (Hb) decorrem de mutações nos genes da globina. As variantes
estruturais mais frequentes são HbS, HbC, HbD e HbE. O gene da hemoglobina S tem …

Background In this study, we evaluate the association of different clinical profiles, laboratory
and genetic biomarkers in patients with sickle cell anemia (SCA) and hemoglobin SC …

Sickle cell hemoglobin is the result of a mutation at the sixth amino acid position of the beta
(β) globin chain. The HBB* S gene is in linkage disequilibrium with five main haplotypes in …

This study focused on clinical, hematological, and molecular aspects of sickle cell anemia
pediatric patients from two different cites in Brazil. Seventy-one patients from São Paulo and …

In sickle cell anemia (SCA), beta S-globin haplotypes represent the ethnic group or
geographic region from which patients originated. The haplotypes include Senegal (SEN) …

Beta S-globin gene (βS-globin) haplotypes, markers for severe sickle cell anemia (SCA),
and the alpha-thalassemia 2 gene 3.7 kb deletion (-α2 (3.7 kb) thal) along with demographic …

This work proposed the diagnosis of iron deficiency anemia (IDA) and sickle cell disease
(SCD) in human blood caused by iron deficiency and hemoglobin S (HbS), which are …