Factor XIa (FXIa) in the intrinsic pathway of the coagulation process has been proven to be
an effective and safe target for anticoagulant discovery with limited or no bleeding …

Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm), and it plays a
crucial role in fibrinolysis as well as wound healing, immunity, tissue remodeling and …

Hyperfibrinolytic situations can lead to life-threatening bleeding, especially during cardiac
surgery. The approved antifibrinolytic agents such as tranexamic acid, ε-aminocaproic acid …

MDA-9/Syntenin, a key scaffolding protein and a molecular hub involved in a diverse range
of cell signaling responses, has proved to be a challenging target for the design and …

Targeting of cancer stem cells (CSC) is expected to be a paradigm-shifting approach for the
treatment of cancers. Cell surface proteoglycans bearing sulfated glycosaminoglycan (GAG) …

Antifibrinolytic drugs provide important pharmacological interventions to reduce morbidity
and mortality from excessive bleeding during surgery and after trauma. Current drugs used …

Vitamin K antagonists (VKA) have long been the default drugs for anticoagulant
management in venous thrombosis. While efficacious, they are difficult to use due to …

Enzymes are an important class of biomacromolecules which catalyze many metabolic
processes in living systems. Nanomaterials can be synthesized with tailored sizes as well as …

Although heparan sulfate (HS) has been implicated in facilitating entry of enveloped viruses
including herpes simplex virus (HSV), small molecules that effectively compete with this …

Natural glycosaminoglycans (GAGs) are arguably the most diverse collection of natural
products. Unfortunately, this bounty of structures remains untapped. Decades of research …