Hyaluronic acid: redefining its role

G Abatangelo, V Vindigni, G Avruscio, L Pandis, P Brun - Cells, 2020 - mdpi.com
The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has
promoted new research impetus for biologists and, the clinical interest in several fields of …

Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer

AG Tavianatou, I Caon, M Franchi… - The FEBS …, 2019 - Wiley Online Library
Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

[HTML][HTML] Development and application of hyaluronic acid in tumor targeting drug delivery

Z Luo, Y Dai, H Gao - Acta Pharmaceutica Sinica B, 2019 - Elsevier
Hyaluronic acid (HA) is a natural polysaccharide that has gained much attention due to its
biocompatibility, enzyme degradation capacity and active tumor targeting capacity. Its …

Hyaluronic acid for anticancer drug and nucleic acid delivery

F Dosio, S Arpicco, B Stella, E Fattal - Advanced drug delivery reviews, 2016 - Elsevier
Hyaluronic acid (HA) is widely used in anticancer drug delivery, since it is biocompatible,
biodegradable, non-toxic, and non-immunogenic; moreover, HA receptors are …

Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes

CM Beaufort, JCA Helmijr, AM Piskorz, M Hoogstraat… - PloS one, 2014 - journals.plos.org
Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal
gynaecological malignancy in the Western world. Therapeutic approaches need to account …

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

M Zöller - Nature Reviews Cancer, 2011 - nature.com
Can an abundantly expressed molecule be a reliable marker for the cancer-initiating cells
(CICs; also known as cancer stem cells), which constitute the minority of cells within the …

Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguity

A Jaggupilli, E Elkord - Journal of Immunology Research, 2012 - Wiley Online Library
Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis,
heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a …

Hyaluronic acid bioconjugates for the delivery of bioactive molecules

A Mero, M Campisi - Polymers, 2014 - mdpi.com
Hyaluronic acid (HA) has currently several therapeutic applications: in ophthalmology,
osteoarthritis, wound healing, tissue regeneration, postoperative anti-adhesion and …

Advanced nanomedicine approaches applied for treatment of skin carcinoma

H Kaur, P Kesharwani - Journal of Controlled Release, 2021 - Elsevier
Skin-cancer is the commonest malignancy affecting huge proportion of the population,
reaching heights in terms of morbidity. The treatment strategies are presently focusing on …

Hyaluronate and its derivatives for customized biomedical applications

H Kim, H Jeong, S Han, S Beack, BW Hwang, M Shin… - Biomaterials, 2017 - Elsevier
Since hyaluronate (HA) was firstly isolated from the vitreous of bovine eyes in 1934, HA has
been widely investigated for various biomedical applications. As a naturally-occurring …