The Central Role of PI3K in Cell Signaling Phosphatidylinositol 3-kinase (PI3K) is involved
in multiple cell processes, including insulin signaling, cell growth, immunity, and brain …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective
treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics …

Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …

Background Body size in sheep is an important indicator of productivity, growth and health
as well as of environmental adaptation. It is a composite quantitative trait that has been …

PIK3R1 (also known as p85α) is a regulatory subunit of phosphoinositide 3-kinases (PI3Ks).
PI3K, a heterodimer of a regulatory subunit and a catalytic subunit, phosphorylates …

Recent genetic studies have highlighted the potential involvement of melatonin receptor 1
(MT 1) and melatonin receptor 2 (MT 2) in the pathogenesis of type 2 diabetes. Here, we …

Adipose tissue macrophages (ATMs) display tremendous heterogeneity depending on
signals in their local microenvironment and contribute to the pathogenesis of obesity. The …

Abstract Phosphoinositide 3-kinase (PI3K) is responsible for phosphorylating
phosphoinositides to generate secondary signaling molecules crucial for regulating various …